@article{fitzgerald2026cart,article_type={News and Views},title={A boost for CAR T cell therapy},author={Fitzgerald, Emily and Padilla, Marshall S. and Mitchell, Michael J.},journal={Nature Materials},year={2026},doi={10.1038/s41563-026-02725-0}}
Adv. Mater.
Research Article
Lipid nanoparticle co-delivery of mRNA and a small molecule drug for oral cancer chemoimmunotherapy
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Mohamad-Gabriel Alameh, Drew Weissman, Anh D. Le, and Michael J. Mitchell
@article{padilla2026oral,article_type={Research Article},title={Lipid nanoparticle co-delivery of mRNA and a small molecule drug for oral cancer chemoimmunotherapy},author={Padilla, Marshall S. and Li, Jacqueline J. and Zhang, Qunzhou and Patwari, Korey and Shi, Shihong and Yamagata, Hannah M. and Joseph, Ryann A. and Hymms, Briyanna N. and Teerdhala, Sridatta V. and Alameh, Mohamad-Gabriel and Weissman, Drew and Le, Anh D. and Mitchell, Michael J.},journal={Advanced Materials},year={2026},doi={10.1002/adma.73721}}
Nano Lett.
Research Article
Enhancing lipid nanoparticle-mediated circular RNA and mRNA expression in the placenta through inhibition of IFNAR-JAK-STAT signaling
Hannah C. Safford, Hannah C. Geisler, Ajay S. Thatte, Kuo-Chieh. Liao, Marshall S. Padilla, Hannah M. Yamagata, Amanda M. Murray, Anushka. Agrawal, Alexandre. Poirier, Alex G. Hamilton, Kelsey L. Swingle, Emily. Fitzgerald, Ori Chalom, Yue Wan, and Michael J. Mitchell
@article{safford2026circrna,article_type={Research Article},title={Enhancing lipid nanoparticle-mediated circular RNA and mRNA expression in the placenta through inhibition of IFNAR-JAK-STAT signaling},author={Safford, Hannah C. and Geisler, Hannah C. and Thatte, Ajay S. and Liao, Kuo-Chieh. and Padilla, Marshall S. and Yamagata, Hannah M. and Murray, Amanda M. and Agrawal, Anushka. and Poirier, Alexandre. and Hamilton, Alex G. and Swingle, Kelsey L. and Fitzgerald, Emily. and Chalom, Ori and Wan, Yue and Mitchell, Michael J.},journal={Nano Letters},year={2026},doi={10.1021/acs.nanolett.6c01762}}
Adv. Mater.
Research Article
Resolving heterogeneity of targeted lipid nanoparticles through solution-based biophysical analyses
Hannah C. Geisler, Hannah C. Safford, Ajay S. Thatte, Marshall S. Padilla, Elisa Battistini, Hannah M. Yamagata, Violet M. Ullman, Alex Chan, Benjamin E. Nachod, Anushka Agrawal, Maxwell B. Watkins, Jesse B. Hopkins, Andrew Tsourkas, Kushol Gupta, and Michael J. Mitchell
@article{geisler2026tlnp,article_type={Research Article},title={Resolving heterogeneity of targeted lipid nanoparticles through solution-based biophysical analyses},author={Geisler, Hannah C. and Safford, Hannah C. and Thatte, Ajay S. and Padilla, Marshall S. and Battistini, Elisa and Yamagata, Hannah M. and Ullman, Violet M. and Chan, Alex and Nachod, Benjamin E. and Agrawal, Anushka and Watkins, Maxwell B. and Hopkins, Jesse B. and Tsourkas, Andrew and Gupta, Kushol and Mitchell, Michael J.},journal={Advanced Materials},year={2026},doi={10.1002/adma.73984}}
PNAS
Research Article
mRNA lipid nanoparticle cancer vaccine platform delivering multiple STING activators for enhanced antitumor activity
Ye Zeng, Junchao Xu, Jinjin Wang, Lulu Xue, Jiageng Liu, Hannah C. Geisler, Xu Ma, Jilian R. Melamed, Qiangqiang Shi, Marshall S. Padilla, Zhangyi Luo, Jingcheng Zhu, Ajay S. Thatte, Christian G. Figueroa-Espada, Melgious Jin Yan Ang, Amanda M. Murray, Hannah M. Yamagata, Dongyoon Kim, Ann E. Metzloff, Drew Weissman, and Michael J. Mitchell
Proceedings of the National Academy of Sciences, 2026
@article{zeng2026sting,article_type={Research Article},title={mRNA lipid nanoparticle cancer vaccine platform delivering multiple STING activators for enhanced antitumor activity},author={Zeng, Ye and Xu, Junchao and Wang, Jinjin and Xue, Lulu and Liu, Jiageng and Geisler, Hannah C. and Ma, Xu and Melamed, Jilian R. and Shi, Qiangqiang and Padilla, Marshall S. and Luo, Zhangyi and Zhu, Jingcheng and Thatte, Ajay S. and Figueroa-Espada, Christian G. and Ang, Melgious Jin Yan and Murray, Amanda M. and Yamagata, Hannah M. and Kim, Dongyoon and Metzloff, Ann E. and Weissman, Drew and Mitchell, Michael J.},journal={Proceedings of the National Academy of Sciences},volume={123},number={28},pages={e2525718123},year={2026},doi={10.1073/pnas.2525718123}}
Nat. Protoc.
Protocol
Preparation of targeted lipid nanoparticles for precision nucleic acid delivery
Hannah C. Geisler, Elisa Battistini, Ajay S. Thatte, Marshall S. Padilla, and Michael J. Mitchell
@article{geisler2026protocols,article_type={Protocol},title={Preparation of targeted lipid nanoparticles for precision nucleic acid delivery},author={Geisler, Hannah C. and Battistini, Elisa and Thatte, Ajay S. and Padilla, Marshall S. and Mitchell, Michael J.},journal={Nature Protocols},note={In press},year={2026},doi={10.1038/s41596-025-01330-w}}
JACS
Research Article
Aromatic mRNA lipid nanoparticle (aroLNP) platform confers lymph node tropism and vaccine protection with reduced liver delivery
Hannah M. Yamagata, Marshall S. Padilla, Alex G. Hamilton, Kelsey L. Swingle, Adele S. Ricciardi, Ajay S. Thatte, Ryann A. Joseph, Ori Chalom, Hannah C. Geisler, Jacqueline J. Li, Akash Agrawal, Sherry Du, Dongyoon Kim, Rachel Whitaker, Christian G. Figueroa-Espada, Emily L. Han, Amanda M. Murray, Mohamad-Gabriel Alameh, Drew Weissman, and Michael J. Mitchell
@article{yamagata2026arolnp,article_type={Research Article},title={Aromatic mRNA lipid nanoparticle (aroLNP) platform confers lymph node tropism and vaccine protection with reduced liver delivery},author={Yamagata, Hannah M. and Padilla, Marshall S. and Hamilton, Alex G. and Swingle, Kelsey L. and Ricciardi, Adele S. and Thatte, Ajay S. and Joseph, Ryann A. and Chalom, Ori and Geisler, Hannah C. and Li, Jacqueline J. and Agrawal, Akash and Du, Sherry and Kim, Dongyoon and Whitaker, Rachel and Figueroa-Espada, Christian G. and Han, Emily L. and Murray, Amanda M. and Alameh, Mohamad-Gabriel and Weissman, Drew and Mitchell, Michael J.},journal={Journal of the American Chemical Society},volume={148},pages={14137--14150},year={2026},doi={10.1021/jacs.6c00080}}
ACS Nano
Research Article
Automated and parallelized microfluidic generation of large and precisely-defined lipid nanoparticle libraries
Andrew R. Hanna, Sarah J. Shepherd, Gregory A. Datto, Ian Navarro, Adele S. Ricciardi, Marshall S. Padilla, Neha Srikumar, Sheng Zhang, Hannah M. Yamagata, Nina Y. Meng, Joshua R. Buser, Michael J. Mitchell, and David Issadore
@article{hanna2026microfluidic,article_type={Research Article},title={Automated and parallelized microfluidic generation of large and precisely-defined lipid nanoparticle libraries},author={Hanna, Andrew R. and Shepherd, Sarah J. and Datto, Gregory A. and Navarro, Ian and Ricciardi, Adele S. and Padilla, Marshall S. and Srikumar, Neha and Zhang, Sheng and Yamagata, Hannah M. and Meng, Nina Y. and Buser, Joshua R. and Mitchell, Michael J. and Issadore, David},journal={ACS Nano},volume={20},pages={772--789},year={2026},doi={10.1021/acsnano.5c15613}}
2025
Nat. Commun.
Research Article
Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering
Marshall S. Padilla, Kaitlin Mrksich, Yiming Wang, Rebecca M. Haley, Jacqueline J. Li, Emily L. Han, Rakan El-Mayta, Emily H. Kim, Sofia Dias, Ningqiang Gong, Sridatta V. Teerdhala, Xuexiang Han, Vivek Chowdhary, Lulu Xue, Zain Siddiqui, Hannah M. Yamagata, Dongyoon Kim, Il-Chul Yoon, James M. Wilson, Ravi Radhakrishnan, and Michael J. Mitchell
@article{padilla2025bend,article_type={Research Article},title={Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering},author={Padilla, Marshall S. and Mrksich, Kaitlin and Wang, Yiming and Haley, Rebecca M. and Li, Jacqueline J. and Han, Emily L. and El-Mayta, Rakan and Kim, Emily H. and Dias, Sofia and Gong, Ningqiang and Teerdhala, Sridatta V. and Han, Xuexiang and Chowdhary, Vivek and Xue, Lulu and Siddiqui, Zain and Yamagata, Hannah M. and Kim, Dongyoon and Yoon, Il-Chul and Wilson, James M. and Radhakrishnan, Ravi and Mitchell, Michael J.},journal={Nature Communications},volume={16},pages={996},year={2025},doi={10.1038/s41467-024-55137-6}}
Nat. Biotechnol.
Research Article
Elucidating lipid nanoparticle properties and structure through biophysical analyses
Marshall S. Padilla, Sarah J. Shepherd, Andrew R. Hanna, Martin Kurnik, Xujun Zhang, Michelle Chen, James Byrnes, Ryann A. Joseph, Hannah M. Yamagata, Adele S. Ricciardi, Kaitlin Mrksich, David Issadore, Kushol Gupta, and Michael J. Mitchell
@article{padilla2025biophysical,article_type={Research Article},title={Elucidating lipid nanoparticle properties and structure through biophysical analyses},author={Padilla, Marshall S. and Shepherd, Sarah J. and Hanna, Andrew R. and Kurnik, Martin and Zhang, Xujun and Chen, Michelle and Byrnes, James and Joseph, Ryann A. and Yamagata, Hannah M. and Ricciardi, Adele S. and Mrksich, Kaitlin and Issadore, David and Gupta, Kushol and Mitchell, Michael J.},journal={Nature Biotechnology},note={In press},year={2025},doi={10.1038/s41587-025-02855-x}}
Nat. Biotechnol.
Research Briefing
Solution biophysics reveals the polydisperse structure of RNA lipid nanoparticles
Marshall S. Padilla, Kushol Gupta, and Michael J. Mitchell
@article{padilla2025solutionbiophysics,article_type={Research Briefing},title={Solution biophysics reveals the polydisperse structure of RNA lipid nanoparticles},author={Padilla, Marshall S. and Gupta, Kushol and Mitchell, Michael J.},journal={Nature Biotechnology},note={In press},year={2025},doi={10.1038/s41587-025-02909-0}}
Nano Lett.
Research Article
Cas9 protein enhances lipid nanoparticle-mediated CFTR repair compared to mRNA
Ryann A. Joseph, Rebecca M. Haley, Marshall S. Padilla, Adele S. Ricciardi, Hannah M. Yamagata, and Michael J. Mitchell
@article{joseph2025cas9,article_type={Research Article},title={Cas9 protein enhances lipid nanoparticle-mediated CFTR repair compared to mRNA},author={Joseph, Ryann A. and Haley, Rebecca M. and Padilla, Marshall S. and Ricciardi, Adele S. and Yamagata, Hannah M. and Mitchell, Michael J.},journal={Nano Letters},volume={25},pages={14348--14355},year={2025},doi={10.1021/acs.nanolett.5c03548}}
ACS Nano
Research Article
Lipid nanoparticles for in vivo lung delivery of CRISPR-Cas9 ribonucleoproteins allow gene editing of clinical targets
Rebecca M. Haley, Marshall S. Padilla, Rakan D. El-Mayta, Ryann A. Joseph, Jamie A. Weber, Christian G. Figueroa-Espada, Alvin J. Mukalel, Adele S. Ricciardi, Rohan Palanki, Hannah C. Geisler, Margaret T. Jester, Beverly L. Davidson, and Michael J. Mitchell
@article{haley2025lung,article_type={Research Article},title={Lipid nanoparticles for in vivo lung delivery of CRISPR-Cas9 ribonucleoproteins allow gene editing of clinical targets},author={Haley, Rebecca M. and Padilla, Marshall S. and El-Mayta, Rakan D. and Joseph, Ryann A. and Weber, Jamie A. and Figueroa-Espada, Christian G. and Mukalel, Alvin J. and Ricciardi, Adele S. and Palanki, Rohan and Geisler, Hannah C. and Jester, Margaret T. and Davidson, Beverly L. and Mitchell, Michael J.},journal={ACS Nano},volume={19},pages={13790--13804},year={2025},doi={10.1021/acsnano.4c16617}}
2024
Eur. J. Immunol.
Review
Lipid nanoparticle-mediated RNA delivery for immune cell modulation
Emily H.* Kim, Sridatta V.* Teerdhala, Marshall S.* Padilla, Ryann A. Joseph, Jacqueline J. Li, Rebecca M. Haley, and Michael J. Mitchell
@article{kim2024immune,article_type={Review},title={Lipid nanoparticle-mediated RNA delivery for immune cell modulation},author={Kim, Emily H. and Teerdhala, Sridatta V. and Padilla, Marshall S. and Joseph, Ryann A. and Li, Jacqueline J. and Haley, Rebecca M. and Mitchell, Michael J.},journal={European Journal of Immunology},volume={54},pages={2451008},year={2024},doi={10.1002/eji.202451008}}
Adv. Drug Deliv. Rev.
Review
Breaking the final barrier: evolution of cationic and ionizable lipid structure in lipid nanoparticles to escape the endosome
Kaitlin* Mrksich, Marshall S.* Padilla, and Michael J. Mitchell
@article{mrksich2024endosome,article_type={Review},title={Breaking the final barrier: evolution of cationic and ionizable lipid structure in lipid nanoparticles to escape the endosome},author={Mrksich, Kaitlin and Padilla, Marshall S. and Mitchell, Michael J.},journal={Advanced Drug Delivery Reviews},volume={214},pages={115446},year={2024},doi={10.1016/j.addr.2024.115446}}
J. Mol. Liq.
Review
Probing ionic liquid toxicity through biophysical and computational methods
@article{padilla2024ionicliquid,article_type={Review},title={Probing ionic liquid toxicity through biophysical and computational methods},author={Padilla, Marshall S. and Mecozzi, Sandro},journal={Journal of Molecular Liquids},volume={395},pages={123886},year={2024},doi={10.1016/j.molliq.2023.123886}}
Nano Lett.
Research Article
Peptide-functionalized lipid nanoparticles for targeted systemic mRNA delivery to the brain
Emily L. Han, Sophia Tang, Dongyoon Kim, Amanda M. Murray, Kelsey L. Swingle, Alex G. Hamilton, Kaitlin Mrksich, Marshall S. Padilla, Rohan Palanki, Jacqueline J. Li, and Michael J. Mitchell
@article{han2024brain,article_type={Research Article},title={Peptide-functionalized lipid nanoparticles for targeted systemic mRNA delivery to the brain},author={Han, Emily L. and Tang, Sophia and Kim, Dongyoon and Murray, Amanda M. and Swingle, Kelsey L. and Hamilton, Alex G. and Mrksich, Kaitlin and Padilla, Marshall S. and Palanki, Rohan and Li, Jacqueline J. and Mitchell, Michael J.},journal={Nano Letters},volume={25},pages={800--810},year={2024},doi={10.1021/acs.nanolett.4c05186}}
Nat. Chem.
Research Article
Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo
Xuexiang Han, Mohamad-Gabriel Alameh, Ningqiang Gong, Lulu Xue, Majed Ghattas, Giridhar Bojja, Junchao Xu, Gan Zhao, Claude C. Warzecha, Marshall S. Padilla, Rakan El-Mayta, Garima Dwivedi, Yiming Xu, Andrew E. Vaughan, James M. Wilson, Drew Weissman, and Michael J. Mitchell
@article{han2024amidine,article_type={Research Article},title={Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo},author={Han, Xuexiang and Alameh, Mohamad-Gabriel and Gong, Ningqiang and Xue, Lulu and Ghattas, Majed and Bojja, Giridhar and Xu, Junchao and Zhao, Gan and Warzecha, Claude C. and Padilla, Marshall S. and El-Mayta, Rakan and Dwivedi, Garima and Xu, Yiming and Vaughan, Andrew E. and Wilson, James M. and Weissman, Drew and Mitchell, Michael J.},journal={Nature Chemistry},volume={16},pages={1687--1697},year={2024},doi={10.1038/s41557-024-01557-2}}
Nano Lett.
Research Article
Predictive high-throughput platform for dual screening of mRNA lipid nanoparticle blood-brain barrier transfection and crossing
Emily L. Han, Marshall S. Padilla, Rohan Palanki, Dongyoon Kim, Kaitlin Mrksich, Jacqueline J. Li, Sophia Tang, Il-Chul Yoon, and Michael J. Mitchell
@article{han2024bbb,article_type={Research Article},title={Predictive high-throughput platform for dual screening of mRNA lipid nanoparticle blood-brain barrier transfection and crossing},author={Han, Emily L. and Padilla, Marshall S. and Palanki, Rohan and Kim, Dongyoon and Mrksich, Kaitlin and Li, Jacqueline J. and Tang, Sophia and Yoon, Il-Chul and Mitchell, Michael J.},journal={Nano Letters},volume={24},pages={1477--1486},year={2024},doi={10.1021/acs.nanolett.3c03509}}
Adv. Mater.
Research Article
Antigen presenting cell mimetic lipid nanoparticles for rapid mRNA CAR T cell cancer immunotherapy
Ann E. Metzloff, Marshall S. Padilla, Ningqiang Gong, Margaret M. Billingsley, Xuexiang Han, Maria Merolle, Dan Mai, Christian G. Figueroa-Espada, Ajay S. Thatte, Rebecca M. Haley, Alvin J. Mukalel, Alex G. Hamilton, Mohamad-Gabriel Alameh, Drew Weissman, Neil C. Sheppard, Carl H. June, and Michael J. Mitchell
@article{metzloff2024apc,article_type={Research Article},title={Antigen presenting cell mimetic lipid nanoparticles for rapid mRNA CAR T cell cancer immunotherapy},author={Metzloff, Ann E. and Padilla, Marshall S. and Gong, Ningqiang and Billingsley, Margaret M. and Han, Xuexiang and Merolle, Maria and Mai, Dan and Figueroa-Espada, Christian G. and Thatte, Ajay S. and Haley, Rebecca M. and Mukalel, Alvin J. and Hamilton, Alex G. and Alameh, Mohamad-Gabriel and Weissman, Drew and Sheppard, Neil C. and June, Carl H. and Mitchell, Michael J.},journal={Advanced Materials},volume={36},pages={2313226},year={2024},doi={10.1002/adma.202313226}}
J. Biomed. Mater. Res. A
Research Article
Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length
Kaitlin Mrksich, Marshall S. Padilla, Ryann A. Joseph, Emily L. Han, Dongyoon Kim, Rohan Palanki, Junchao Xu, and Michael J. Mitchell
Journal of Biomedical Materials Research Part A, 2024
@article{mrksich2024taillength,article_type={Research Article},title={Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length},author={Mrksich, Kaitlin and Padilla, Marshall S. and Joseph, Ryann A. and Han, Emily L. and Kim, Dongyoon and Palanki, Rohan and Xu, Junchao and Mitchell, Michael J.},journal={Journal of Biomedical Materials Research Part A},volume={112},pages={1494--1505},year={2024},doi={10.1002/jbm.a.37705}}
J. Control. Release
Research Article
EGFR-targeted ionizable lipid nanoparticles enhance in vivo mRNA delivery to the placenta
Hannah C. Geisler, Aditya A. Ghalsasi, Hannah C. Safford, Kelsey L. Swingle, Ajay S. Thatte, Alvin J. Mukalel, Ningqiang Gong, Alex G. Hamilton, Emily L. Han, Benjamin E. Nachod, Marshall S. Padilla, and Michael J. Mitchell
@article{geisler2024egfr,article_type={Research Article},title={EGFR-targeted ionizable lipid nanoparticles enhance in vivo mRNA delivery to the placenta},author={Geisler, Hannah C. and Ghalsasi, Aditya A. and Safford, Hannah C. and Swingle, Kelsey L. and Thatte, Ajay S. and Mukalel, Alvin J. and Gong, Ningqiang and Hamilton, Alex G. and Han, Emily L. and Nachod, Benjamin E. and Padilla, Marshall S. and Mitchell, Michael J.},journal={Journal of Controlled Release},volume={371},pages={455--469},year={2024},doi={10.1016/j.jconrel.2024.05.036}}
Adv. Funct. Mater.
Research Article
Oxidized mRNA lipid nanoparticles for in situ chimeric antigen receptor monocyte engineering
Alvin J. Mukalel, Alex G. Hamilton, Margaret M. Billingsley, Jacqueline Li, Ajay S. Thatte, Xuexiang Han, Hannah C. Safford, Marshall S. Padilla, Tyler Papp, Hamideh Parhiz, Drew Weissman, and Michael J. Mitchell
@article{mukalel2024oxidized,article_type={Research Article},title={Oxidized mRNA lipid nanoparticles for in situ chimeric antigen receptor monocyte engineering},author={Mukalel, Alvin J. and Hamilton, Alex G. and Billingsley, Margaret M. and Li, Jacqueline and Thatte, Ajay S. and Han, Xuexiang and Safford, Hannah C. and Padilla, Marshall S. and Papp, Tyler and Parhiz, Hamideh and Weissman, Drew and Mitchell, Michael J.},journal={Advanced Functional Materials},volume={34},pages={2312038},year={2024},doi={10.1002/adfm.202312038}}
2023
J. Pharm. Sci.
Research Article
MCT nanoemulsions for the efficient delivery of siRNA
Marshall S. Padilla, Montri Tangsangasaksri, Chia-Chih Chang, and Sandro Mecozzi
@article{padilla2023mct,article_type={Research Article},title={MCT nanoemulsions for the efficient delivery of siRNA},author={Padilla, Marshall S. and Tangsangasaksri, Montri and Chang, Chia-Chih and Mecozzi, Sandro},journal={Journal of Pharmaceutical Sciences},volume={113},pages={764--771},year={2023},doi={10.1016/j.xphs.2023.11.013}}
ACS Appl. Mater. Interfaces
Research Article
Lipid nanoparticle delivery of small proteins for potent in vivo RAS inhibition
Rebecca M. Haley, Alexander Chan, Margaret M. Billingsley, Ningqiang Gong, Marshall S. Padilla, Emily H. Kim, Hejia Wang, Dongni Yin, Kirk J. Wangensteen, Andrew Tsourkas, and Michael J. Mitchell
@article{haley2023ras,article_type={Research Article},title={Lipid nanoparticle delivery of small proteins for potent in vivo RAS inhibition},author={Haley, Rebecca M. and Chan, Alexander and Billingsley, Margaret M. and Gong, Ningqiang and Padilla, Marshall S. and Kim, Emily H. and Wang, Hejia and Yin, Dongni and Wangensteen, Kirk J. and Tsourkas, Andrew and Mitchell, Michael J.},journal={ACS Applied Materials \& Interfaces},volume={15},pages={21877--21892},year={2023},doi={10.1021/acsami.3c01501}}
Int. J. Nanomedicine
Research Article
Delivery of plasmid DNA by ionizable lipid nanoparticles to induce CAR expression in T cells
Pedro H. D. M. Prazeres, Heloisa Ferreira, Pedro A. C. Costa, Walison Silva, Marco T. Alves, Marshall Padilla, Ajay Thatte, Anderson K. Santos, Anderson O. Lobo, Adriano Sabino, Helen L. Del Puerto, Michael J. Mitchell, and Pedro P. G. Guimaraes
@article{prazeres2023plasmid,article_type={Research Article},title={Delivery of plasmid DNA by ionizable lipid nanoparticles to induce CAR expression in T cells},author={Prazeres, Pedro H. D. M. and Ferreira, Heloisa and Costa, Pedro A. C. and da Silva, Walison and Alves, Marco T. and Padilla, Marshall and Thatte, Ajay and Santos, Anderson K. and Lobo, Anderson O. and Sabino, Adriano and Del Puerto, Helen L. and Mitchell, Michael J. and Guimaraes, Pedro P. G.},journal={International Journal of Nanomedicine},volume={18},pages={5891--5904},year={2023},doi={10.2147/IJN.S424723}}
PNAS
Research Article
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines
Sarah J. Shepherd, Xuexiang Han, Alvin J. Mukalel, Rakan El-Mayta, Ajay S. Thatte, Jingya Wu, Marshall S. Padilla, Mohamad-Gabriel Alameh, Neha Srikumar, Daeyeon Lee, Drew Weissman, David Issadore, and Michael J. Mitchell
Proceedings of the National Academy of Sciences, 2023
@article{shepherd2023vaccine,article_type={Research Article},title={Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines},author={Shepherd, Sarah J. and Han, Xuexiang and Mukalel, Alvin J. and El-Mayta, Rakan and Thatte, Ajay S. and Wu, Jingya and Padilla, Marshall S. and Alameh, Mohamad-Gabriel and Srikumar, Neha and Lee, Daeyeon and Weissman, Drew and Issadore, David and Mitchell, Michael J.},journal={Proceedings of the National Academy of Sciences},volume={120},pages={e2303567120},year={2023},doi={10.1073/pnas.2303567120}}
JACS
Research Article
Ionizable lipid nanoparticles for in vivo mRNA delivery to the placenta during pregnancy
Kelsey L. Swingle, Hannah C. Safford, Hannah C. Geisler, Alex G. Hamilton, Ajay S. Thatte, Margaret M. Billingsley, Ryann A. Joseph, Kaitlin Mrksich, Marshall S. Padilla, Aditya A. Ghalsasi, Mohamad-Gabriel Alameh, Drew Weissman, and Michael J. Mitchell
@article{swingle2023placenta,article_type={Research Article},title={Ionizable lipid nanoparticles for in vivo mRNA delivery to the placenta during pregnancy},author={Swingle, Kelsey L. and Safford, Hannah C. and Geisler, Hannah C. and Hamilton, Alex G. and Thatte, Ajay S. and Billingsley, Margaret M. and Joseph, Ryann A. and Mrksich, Kaitlin and Padilla, Marshall S. and Ghalsasi, Aditya A. and Alameh, Mohamad-Gabriel and Weissman, Drew and Mitchell, Michael J.},journal={Journal of the American Chemical Society},volume={145},pages={4691--4706},year={2023},doi={10.1021/jacs.2c12893}}
Lab Chip
Review
Nanoparticle protein corona: from structure and function to therapeutic targeting
Ghazal Bashiri, Marshall S. Padilla, Kelsey L. Swingle, Sarah J. Shepherd, Michael J. Mitchell, and Karen Wang
@article{bashiri2023corona,article_type={Review},title={Nanoparticle protein corona: from structure and function to therapeutic targeting},author={Bashiri, Ghazal and Padilla, Marshall S. and Swingle, Kelsey L. and Shepherd, Sarah J. and Mitchell, Michael J. and Wang, Karen},journal={Lab on a Chip},volume={23},pages={1432--1466},year={2023},doi={10.1039/D2LC00799A}}
JoVE
Protocol
Testing the in vitro and in vivo efficiency of mRNA-lipid nanoparticles formulated by microfluidic mixing
Rakan El-Mayta, Marshall S. Padilla, Margaret M. Billingsley, Xuexiang Han, and Michael J. Mitchell
@article{elmayta2023jove,article_type={Protocol},title={Testing the in vitro and in vivo efficiency of mRNA-lipid nanoparticles formulated by microfluidic mixing},author={El-Mayta, Rakan and Padilla, Marshall S. and Billingsley, Margaret M. and Han, Xuexiang and Mitchell, Michael J.},journal={Journal of Visualized Experiments},pages={e64810},year={2023},doi={10.3791/64810}}
2022
JACS
Research Article
Rational design of bisphosphonate lipid-like materials for mRNA delivery to the bone microenvironment
Lulu Xue, Ningqiang Gong, Sarah J. Shepherd, Xinhong Xiong, Xinyu Liao, Xuexiang Han, Gan Zhao, Chunhao Song, Hanwen Zhang, Marshall S. Padilla, Jianxin Qin, Yi Shi, Mohamad-Gabriel Alameh, Darrin J. Pochan, Karen Wang, Fei Long, Drew Weissman, and Michael J. Mitchell
@article{xue2022bisphosphonate,article_type={Research Article},title={Rational design of bisphosphonate lipid-like materials for mRNA delivery to the bone microenvironment},author={Xue, Lulu and Gong, Ningqiang and Shepherd, Sarah J. and Xiong, Xinhong and Liao, Xinyu and Han, Xuexiang and Zhao, Gan and Song, Chunhao and Zhang, Hanwen and Padilla, Marshall S. and Qin, Jianxin and Shi, Yi and Alameh, Mohamad-Gabriel and Pochan, Darrin J. and Wang, Karen and Long, Fei and Weissman, Drew and Mitchell, Michael J.},journal={Journal of the American Chemical Society},volume={144},pages={9926--9937},year={2022},doi={10.1021/jacs.2c02706}}
J. Biomed. Mater. Res. A
Research Article
Rational design of anti-inflammatory lipid nanoparticles for mRNA delivery
Hanwen Zhang, Xuexiang Han, Mohamad-Gabriel Alameh, Sarah J. Shepherd, Marshall S. Padilla, Lulu Xue, Kamila Butowska, Drew Weissman, and Michael J. Mitchell
Journal of Biomedical Materials Research Part A, 2022
@article{zhang2022antiinflammatory,article_type={Research Article},title={Rational design of anti-inflammatory lipid nanoparticles for mRNA delivery},author={Zhang, Hanwen and Han, Xuexiang and Alameh, Mohamad-Gabriel and Shepherd, Sarah J. and Padilla, Marshall S. and Xue, Lulu and Butowska, Kamila and Weissman, Drew and Mitchell, Michael J.},journal={Journal of Biomedical Materials Research Part A},volume={110},pages={1101--1108},year={2022},doi={10.1002/jbm.a.37356}}
2021
Green Chem.
Research Article
Expanding the structural diversity of hydrophobic ionic liquids: physicochemical properties and toxicity of Gemini ionic liquids
Marshall S. Padilla, Colin Bertz, Nicole Berdusco, and Sandro Mecozzi
@article{padilla2021gemini,article_type={Research Article},title={Expanding the structural diversity of hydrophobic ionic liquids: physicochemical properties and toxicity of Gemini ionic liquids},author={Padilla, Marshall S. and Bertz, Colin and Berdusco, Nicole and Mecozzi, Sandro},journal={Green Chemistry},volume={23},pages={4375--4385},year={2021},doi={10.1039/D1GC00742D}}
2018
Bioorg. Med. Chem. Lett.
Research Article
Investigation of copper-free alkyne/azide 1,3-dipolar cycloadditions using microwave irradiation
Lindsay E. Chatkewitz, John F. Halonski, Marshall S. Padilla, and Douglas D. Young
@article{chatkewitz2018microwave,article_type={Research Article},title={Investigation of copper-free alkyne/azide 1,3-dipolar cycloadditions using microwave irradiation},author={Chatkewitz, Lindsay E. and Halonski, John F. and Padilla, Marshall S. and Young, Douglas D.},journal={Bioorganic \& Medicinal Chemistry Letters},volume={28},pages={81--84},year={2018},doi={10.1016/j.bmcl.2017.12.007}}
2016
Tetrahedron Lett.
Research Article
Synthesis and incorporation of a caged tyrosine amino acid possessing a bioorthogonal handle
Marshall S. Padilla, Connor A. Farley, Lindsay E. Chatkewitz, and Douglas D. Young
@article{padilla2016tyrosine,article_type={Research Article},title={Synthesis and incorporation of a caged tyrosine amino acid possessing a bioorthogonal handle},author={Padilla, Marshall S. and Farley, Connor A. and Chatkewitz, Lindsay E. and Young, Douglas D.},journal={Tetrahedron Letters},volume={57},pages={4709--4712},year={2016},doi={10.1016/j.tetlet.2016.09.033}}
2015
Bioorg. Med. Chem. Lett.
Research Article
Photosensitive GFP mutants containing an azobenzene unnatural amino acid
@article{padilla2015azobenzene,article_type={Research Article},title={Photosensitive GFP mutants containing an azobenzene unnatural amino acid},author={Padilla, Marshall S. and Young, Douglas D.},journal={Bioorganic \& Medicinal Chemistry Letters},volume={25},pages={470--473},year={2015},doi={10.1016/j.bmcl.2014.12.035}}
2014
Org. Biomol. Chem.
Research Article
Preparation of asymmetrical polyynes by a solid-supported Glaser-Hay reaction
Jason S. Lampkowski, Caitlin E. Durham, Marshall S. Padilla, and Douglas D. Young
@article{lampkowski2014polyynes,article_type={Research Article},title={Preparation of asymmetrical polyynes by a solid-supported Glaser-Hay reaction},author={Lampkowski, Jason S. and Durham, Caitlin E. and Padilla, Marshall S. and Young, Douglas D.},journal={Organic \& Biomolecular Chemistry},volume={13},pages={424--427},year={2014},doi={10.1039/C4OB02196G}}
